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mavacamten will decrease the level or outcome of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Progestin and ethinyl estradiol are CYP3A4 substrates. Mavacamten might decrease systemic exposures of ethinyl estradiol and progestin, which can lead to contraceptive failure or an increa